1. Preheat your oven to 375°F (190°C). Line a baking dish with parchment paper or lightly grease with cooking spray.
2. In a medium-sized bowl, mix together the mayonnaise, Parmesan cheese, garlic powder, onion powder, oregano, and paprika until well combined.
3. Season the chicken breasts with salt and pepper, then place them in the prepared baking dish.
4. Spread the mayonnaise mixture evenly over the top of each chicken breast, ensuring they are fully covered.
5. Bake in the preheated oven for 25-30 minutes, or until the chicken is cooked through and the top is golden brown. Use a meat thermometer to ensure the chicken reaches an internal temperature of 165°F (75°C).
6. Once cooked, remove from the oven and let it rest for a couple of minutes before serving. Garnish with chopped fresh parsley for a pop of color and freshness.

Pro tip from my kitchen to yours: If you’re looking for a bit more crunch, you can sprinkle some breadcrumbs on top before baking. It adds a delightful texture contrast to the creamy topping.