Creating this casserole is a straightforward process, and I’m here to guide you every step of the way, much like my family did on those loud, bustling evenings in our Asheville kitchen.

1. Preheat your oven to 375°F (190°C).
2. In a large skillet, cook the ground beef and Italian sausage over medium heat until browned, about 6-8 minutes. Drain excess fat.
3. Add the chopped onions, minced garlic, and bell peppers to the skillet. Sauté until the vegetables are tender, around 5 minutes.
4. Stir in the marinara sauce, oregano, and basil. Season with salt and pepper to taste. Let the mixture simmer for 5 minutes.
5. In a large baking dish, combine the cooked pasta with the meat sauce. Stir until the pasta is evenly coated.
6. Layer the pepperoni slices over the pasta mixture, then sprinkle with mozzarella and cheddar cheese.
7. Bake in the preheated oven for 20-25 minutes, or until the cheese is bubbly and golden.
8. Let the casserole cool for a few minutes before serving. Enjoy the burst of flavors that remind you of a hearty pizza.

Remember, the key to this dish is in the layering and balance of ingredients. Each element should complement the others, creating a symphony of tastes with every bite.